University Of Tasmania

File(s) under permanent embargo

Skeletal muscle nitric oxide signaling and exercise: a focus on glucose metabolism

journal contribution
posted on 2023-05-17, 13:12 authored by McConell, GK, Stephen RattiganStephen Rattigan, Lee-Young, RS, Wadley, GD, Merry, TL
Nitric oxide (NO) is an important vasodilator and regulator in the cardiovascular system, and this link was the subject of a Nobel prize in 1998. However, NO also plays many other regulatory roles, including thrombosis, immune function, neural activity, and gastrointestinal function. Low concentrations of NO are thought to have important signaling effects. In contrast, high concentrations of NO can interact with reactive oxygen species, causing damage to cells and cellular components. A less-recognized site of NO production is within skeletal muscle, where small increases are thought to have beneficial effects such as regulating glucose uptake and possibly blood flow, but higher levels of production are thought to lead to deleterious effects such as an association with insulin resistance. This review will discuss the role of NO in skeletal muscle during and following exercise, including in mitochondrial biogenesis, muscle efficiency, and blood flow with a particular focus on its potential role in regulating skeletal muscle glucose uptake during exercise.


National Health & Medical Research Council


Publication title

American Journal of Physiology: Endocrinology and Metabolism








Menzies Institute for Medical Research


Amer Physiological Soc

Place of publication

9650 Rockville Pike, Bethesda, USA, Md, 20814

Rights statement

Copyright 2012 the American Physiological Society

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified