Due to the energy crisis and environmental impact caused by fossil fuel energy, improving the efficiency of cooling, power, and energy systems has become one of the most important aspects of energy sectors. Furthermore, renewable energy is now heavily involved in power generation and cooling engineering. These new emerging renewable energy systems are still in the developing phase. The development of highly efficient energy systems will help to promote system applications and increase the users’ acceptance. Thermodynamic and exergy analyses provide better insight into the design, development, optimization, and performance improvement of the traditional cooling, power, and energy systems, as well as the new emerging renewable energy systems. This Special Issue aims to address the current pressing problems in the development of advanced and innovative cooling, power, and energy systems, using thermodynamic and exergy analyses.