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Spectral-Domain Optical Coherence Tomography-Derived Characteristics of Bruch Membrane Opening in a Young Adult Australian Population
PURPOSE: To characterize and quantify Bruch membrane opening (BMO)-based optic nerve head (ONH) parameters in a large, young and healthy, predominantly white population.
DESIGN: Cross-sectional study and reliability analysis.
METHODS: The ONH of 1344 predominantly white subjects were imaged with spectral-domain optical coherence tomography (SD-OCT). A customized script, coded in Matlab, was used to manually segment and measure multiple BMO-based parameters of the ONH. Measurements were compared to those obtained with confocal scanning laser ophthalmoscopy (Heidelberg Retina Tomograph; HRT). Regression analysis was performed to assess the relationship between BMO parameters and other ocular and demographic variables.
RESULTS: Mean BMO disc and neuroretinal rim (NRR) areas ranged from 0.94 to 4.06 mm2 (mean 1.77 ± 0.38 mm2) and 0.94 to 3.99 mm2 (mean 1.56 ± 0.31 mm2), respectively. When compared to the equivalent HRT measurements, SD-OCT-derived measures differed significantly for all comparable ONH parameters (P < .001). The limits of agreement computed from Bland-Altman plots comparing SD-OCT and HRT measurements showed suboptimal agreement between the techniques. Linear regression analysis demonstrated an effect of ethnicity, axial length, and refractive error on BMO-based parameters.
CONCLUSIONS: We have quantified BMO-based parameters in a large cohort of young adults using SD-OCT. These data will be informative in constructing normative profiles for clinical and research purposes in glaucoma diagnosis and management.
History
Publication title
American Journal of OphthalmologyVolume
165Pagination
154-163ISSN
0002-9394Department/School
Menzies Institute for Medical ResearchPublisher
Elsevier Inc.Place of publication
1600 John F Kennedy Bvd, Philadelphia PA 19103 USARights statement
Copyright? 2016 BY ELSEVIER INC. ALL RIGHTS RESERVED.Repository Status
- Restricted