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Spontaneous tumours in C3H-Avy and C3H-AvyfB mice: High incidence in the United States, low incidence in Australia
journal contributionposted on 2023-05-17, 02:31 authored by Sabine, JR, Brian HortonBrian Horton, Wicks, MB
C3H-Avyy and C3H-Avy, fB mice, with a virtual 100% incidence of liver and mammary tumors in the United States, had an almost 0% incidence of these tumors when these mice were bred and reared in Australia, particularly after the first generation. C3H-Avymice, when reared in Australia but provided with U.S. feed and bedding (cedar shavings), also had essentially a 100% incidence of mammary tumors. Although our results did not rule out other possibilities, the implication of cedar as a "carcinogenicâ€ agent was quite clear-cut. These observations, although not yet made on large numbers of mice, provide new parameters for the study and understanding of the development of spontaneous mammary and liver cancer in mice.â€”J Natl Cancer Inst 50: 1237-1242, 1973. Â© 1973 OUP Publishing Ltd.
Publication titleNational Cancer Institute. Journal
Department/SchoolTasmanian Institute of Agriculture (TIA)
PublisherOxford Univ Press Inc
Place of publicationJournals Dept, 2001 Evans Rd, Cary, USA, Nc, 27513