University Of Tasmania

File(s) under permanent embargo

Stability of daptomycin in peritoneal dialysis solutions packaged in dual-compartment infusion bags

journal contribution
posted on 2023-05-18, 12:23 authored by Ramdas, S, Yousaf, F, Madhur ShastriMadhur Shastri, Stephanus WanandyStephanus Wanandy, Syed Razi ZaidiSyed Razi Zaidi, Khandagale, M, Matthew JoseMatthew Jose, Rahul PatelRahul Patel

Background: Intraperitoneal daptomycin is used for the treatment of peritoneal dialysis (PD)-associated peritonitis caused by vancomycin-resistant bacteria. This study investigated the stability of daptomycin in a pH-neutral PD solution.

Methods: Reconstituted solution of daptomycin was added to a total of nine PD bags to obtain a concentration of 20 mg/L and stored at 1 of 3 different temperatures: 4 or 25°C for up to 168 h or 37°C for up to 48 h. Stabilities were determined by visual inspection, pH measurement and high-performance liquid chromatography.

Results: Daptomycin retained more than 90% of its initial concentration for 120, 72 and 12 h at 4°C, 25°C and 37°C, respectively. No physical precipitation or pH change was observed during the study.

Conclusions: Daptomycin in a pH-neutral PD solution is physically and chemically stable for 120 and 12 h at 4°C and 37°C, respectively.


Royal Hobart Hospital Research Foundation


Publication title

European Journal of Hospital Pharmacy








School of Pharmacy and Pharmacology


B M J Group

Place of publication

United Kingdom

Rights statement

Copyright 2015 The Authors

Repository Status

  • Restricted

Socio-economic Objectives

Public health (excl. specific population health) not elsewhere classified

Usage metrics

    University Of Tasmania