University of Tasmania
Browse

File(s) under permanent embargo

Strontium ranelate, a promising disease modifying osteoarthritis drug

journal contribution
posted on 2023-05-19, 16:01 authored by Han, W, Fan, S, Bai, X, Chang-Hai DingChang-Hai Ding
Introduction: The articular cartilage and subchondral bone may have potential crosstalk in the development and progression of osteoarthritis (OA). Strontium ranelate (SrR) has the ability to dissociate the bone remodeling process and to change the balance between bone resorption and bone formation. Its effect on subchondral bone makes it a potential disease- modifying osteoarthritis drug (DMOAD) in the treatment of OA. The aim of the current review is to summarize up-to-date pharmacological and clinical data of SrR for OA treatment.

Areas covered: A literature search was performed on PubMed and European Medicines Agency (EMA) website for all publications and documents related to SrR and OA. References of related studies were searched by hand. Treatment with SrR, especially at the dosage of 2 g/day, was associated with reduced radiographic knee OA progression, and with meaningful clinical improvement. It was also significantly associated with decreased MRI-assessed cartilage volume loss (CVL) and bone marrow lesions (BMLs).

Expert opinion: SrR could be a promising DMOAD particularly for OA patients with bone phenotypes. The clinical efficacy and side effects of SrR for OA treatment need to be further investigated in future clinical trials before clinical application.

History

Publication title

Expert Opinion on Investigational Drugs

Volume

26

Pagination

375-380

ISSN

1354-3784

Department/School

Menzies Institute for Medical Research

Publisher

Ashley Publications Ltd

Place of publication

Unitec House, 3Rd Fl, 2 Albert Place, Finchley Central, London, England, N3 1Qb

Rights statement

© 2017 Informa UK

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC