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Structural Basis for Hemoglobin Capture by Staphylococcus aureus Cell-surface Protein, IsdH
journal contributionposted on 2023-05-17, 08:34 authored by Kumar, KK, Jacques, DA, Pishchany, G, Caradoc-Davies, T, Spirig, T, Malmirchegini, GR, Langley, DB, Dickson, CF, Mackay, JP, Clubb, RT, Skaar, EP, Guss, JM, David GellDavid Gell
Background: Bacteria need iron from the host to establish infection. Results: We report the first structure of hemoglobin bound to a bacterial protein and show that targeted disruption of this interaction can reduce Staphylococcus aureus growth when hemoglobin is the sole iron source. Conclusion: Physical capture of hemoglobin is important for iron uptake by S. aureus. Significance: Hemoglobin receptors may be targets for new antibacterial agents.
Publication titleJournal of Biological Chemistry
Department/SchoolMenzies Institute for Medical Research
PublisherAmer Soc Biochemistry Molecular Biology Inc
Place of publication9650 Rockville Pike, Bethesda, USA, Md, 20814-3996
Rights statementCopyright 2011 The American Society for Biochemistry and Molecular Biology, Inc.