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108782 - Study of levodopa response in Parkinson's disease - observations on rates of motor progression (Author version).pdf (194.98 kB)

Study of levodopa response in Parkinson's disease: observations on rates of motor progression

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posted on 2023-05-18, 19:19 authored by Ding, C, Ganesvaran, G, Jane AltyJane Alty, Clissold, BG, McColl, CD, Reardon, KA, Schiff, M, Srikanth, V, Kempster, PA
Introduction: It is important to understand how the rate of motor progression in PD relates to dopaminergic treatment.

Methods: The methods for this study comprised prospective defined off state measurements of the levodopa response at 3-year intervals over a mean 13.3-year period in 34 patients enrolled before treatment initiation.

Results: Despite worsening of on and off scores, the magnitude of the l-dopa short-duration response is maintained as the disease progresses. A linear mixed-effects regression analysis of off phase motor scores showed a yearly deterioration of 2.3% of the maximum disability score. Greater motor disability at the commencement of treatment was an independent predictor of faster progression. Demented patients had worse motor function than those without dementia (P = 0.02), and motor deficit appeared to accelerate toward the end of the disease course in patients who had died.

Conclusions: These observations should inform clinical trial design for drugs with possible neuroprotective properties.


Publication title

Movement Disorders










Wicking Dementia Research Education Centre


John Wiley & Sons, Inc.

Place of publication

111 River St, Hoboken, NJ 07030 United States

Rights statement

© 2016 International Parkinson and Movement Disorder Society

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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