University Of Tasmania
Browse

File(s) under permanent embargo

Synaptic changes induced by melanocortin signalling

journal contribution
posted on 2023-05-18, 15:21 authored by Vanni CarusoVanni Caruso, Lagerstrom, MC, Olszewski, PK, Fredriksson, R, Schioth, HB
The melanocortin system has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its involvement in memory, nociception, mood disorders and addiction. In this Review, we focus on the role of the melanocortin 4 receptor and provide an integrative view of the molecular mechanisms that lead to melanocortin-induced changes in synaptic plasticity within these diverse physiological systems. We also highlight the importance of melanocortin peptides and receptors in chronic pain syndromes, memory impairments, depression and drug abuse, and the possibility of targeting them for therapeutic purposes.

History

Publication title

Nature Reviews Neuroscience

Volume

15

Pagination

98-110

ISSN

1471-003X

Department/School

School of Pharmacy and Pharmacology

Publisher

Nature Pub. Group

Place of publication

United Kingdom

Rights statement

© 2014 Macmillan Publishers

Repository Status

  • Restricted

Socio-economic Objectives

Diagnosis of human diseases and conditions

Usage metrics

    University Of Tasmania

    Exports