University Of Tasmania

File(s) under permanent embargo

Synthesis and Structure of Methylmercury(II) Complexes of 9-Methylguanine, including the X-Ray Structural Analysis of (9-Methy1guanine)methylmercury(II) Nitrate

journal contribution
posted on 2023-05-25, 22:56 authored by Canty, AJ, Tobias, RS, Chaichit, N, Gatehouse, BM
Methylmercury(II) nitrate reacts with 9-methylguanine (9-MeGua) in water to form solid complexes of stoicheiometry [HgMe(9-MeGuaH-1)], [HgMe(9-MeGua)][NO3], [HgMe(9-MeGua)] [NO3].H2O, and [(HgMe)2(9-MeGuaH-1)][NO3]. Comparison of i.r. spectra of the solid complexes and lH n.m.r. spectra of [2H6]dimethylsulphoxide-soluble (ionic) complexes with spectra of analogous guanosine (Guo) complexes indicates that complexes of 9-MeGua and Guo with similar stoicheiometry have the same mode of binding of Hg(II)Me to the purine ring. The spectra indicate that [HgMe(9-MeGuaH-1)] and [(HgMe)2(9-MeGuaH-1)][NO3] have Hg(II)Me bonded to N(1) and both N(l) and N(7), respectively, and the complexes [HgMe(9-MeGua)][NO3] and [HgMe(9-MeGua)][NO3].H2O have Hg(II)Me bonded to N(7) with retention of a proton at N(1). Crystals of [HgMe(9-MeGua)][NO3] are monoclinic, with a = 4.196(1), b = 15.060(4), c = 18.288(5) A, beta = 90.17(2), Z = 4, and space group P21/c. The structure has been solved by conventional Patterson and Fourier methods and refined by least-squares techniques to R 0.061 for 1152 reflections collected by diffractometer. The complex has Hg(II)Me bound to N(7) with Hg-C 2.06(2), Hg-N(7) 2.09(2) A, and C-Hg-N(7) 175(1). Mercury interacts weakly with nearby nitrate ions, with Hg 0 2.75(2) and 2.99(2) A; the purine ring is planar with the Hg(II)Me group slightly tilted from this plane, Hg being -0.1 68(1) and the carbon atom -0.41 l(25) A from the plane.


Publication title

Journal of the Chemical Society, Dalton Transactions





Publication status

  • Published

Repository Status

  • Restricted

Usage metrics

    University Of Tasmania


    No categories selected