Synthesis of 4-phenylthieno[2,3-c]quinolines via Suzuki-Miyaura cross-couplings
journal contributionposted on 2023-05-21, 13:29 authored by Hyland, IK, Curtis HoCurtis Ho, Vuong, D, Tsai, YA, Lacey, E, Alexander BissemberAlexander Bissember, Jason SmithJason Smith
A small library of previously unreported 4-phenylthieno[3,2-c]quinolines was prepared from a simple thiophene substrate via a modular synthetic strategy that exploited successive palladium-catalyzed crosscoupling reactions. These heterocycles were screened for activity against various bacterial, fungal, parasitic and cancer cell lines, which identified two original 4-(2-methoxyphenyl)-thieno[3,2-c]quinolines that display encouraging antibacterial activity.
Australian Research Council
Department/SchoolSchool of Natural Sciences
PublisherArkat USA, Inc.
Place of publicationUnited States
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