Synthesis of 4-phenylthieno[2,3-c]quinolines via Suzuki-Miyaura cross-couplings
journal contribution
posted on 2023-05-21, 13:29 authored by Hyland, IK, Curtis HoCurtis Ho, Vuong, D, Tsai, YA, Lacey, E, Alexander BissemberAlexander Bissember, Jason SmithJason SmithA small library of previously unreported 4-phenylthieno[3,2-c]quinolines was prepared from a simple thiophene substrate via a modular synthetic strategy that exploited successive palladium-catalyzed crosscoupling reactions. These heterocycles were screened for activity against various bacterial, fungal, parasitic and cancer cell lines, which identified two original 4-(2-methoxyphenyl)-thieno[3,2-c]quinolines that display encouraging antibacterial activity.
Funding
Australian Research Council
History
Publication title
ARKIVOCVolume
2022Issue
4Pagination
110-122ISSN
1551-7012Department/School
School of Natural SciencesPublisher
Arkat USA, Inc.Place of publication
United StatesRights statement
© 2022. The Authors. This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License, (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.Repository Status
- Open
