Synthetic approaches to preparation of physiologically active polycyclic compounds. IV. X-Ray structural analysis of isomers of amino acid derivatives of adamantane

According to the X-ray diffraction data, the major isomer of 1-(N-benzoyl-β-alanyloxy)-4-benzoyl-oxyadamantane obtained by esterification of β-alanine with 5-hydroxyadamantan-2-one and subsequent benzoylation has trans configuration. The trans-cis isomer ratio is 2:1. A similar isomer ratio was found for 1-(N-benzoylphenylisoseryloxy)-4- benzoyloxyadamantane synthesized by an analogous method.