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Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions

journal contribution
posted on 2023-05-20, 08:02 authored by Duczynski, JA, Rebecca FullerRebecca Fuller, Stewart, SG
Herein, we present the use of the tert-butyldimethylsilyl amine (TBDMS-NH2) as a silylating reagent for phenols, benzyl alcohols, and carboxylic acids. Unlike other silyl protection reactions, this reported process with TBDMS-NH2 does not involve the formation of HCl. Importantly, we report the efficacy of this reagent in operating under solvent-free conditions and enabling short reaction times.

History

Publication title

Australian Journal of Chemistry

Volume

69

Issue

10

Pagination

1172-1179

ISSN

0004-9425

Department/School

School of Natural Sciences

Publisher

C S I R O Publishing

Place of publication

150 Oxford St, Po Box 1139, Collingwood, Australia, Victoria, 3066

Rights statement

Copyright The Authors 2016

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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