Tetraploidy with double t(15;17)(q22;q21) in acute promyelocytic leukaemia

Acute promyelocytic leukaemia (APML) is a subtype of acute myeloid leukaemia characterised by the chromosomal translocation t(15;17)(q22;q21) with the PML-RARa fusion gene. Additional chromosomal abnormalities are occasionally found in patients with acute promyelocytic leukaemia. In this report, we describe of tetraploidy with two copies of the t(15;17)(q22;q21) in a patient with acute promyelocytic leukaemia which is an extremely rare occurrence.