University of Tasmania
Browse

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Download (381.59 kB)
journal contribution
posted on 2023-05-21, 10:08 authored by du Sert, NP, Hurst, V, Ahluwalia, A, Alam, S, Avey, MT, Baker, M, Browne, WJ, Clark, A, Cuthill, IC, Dirnagl, U, Emerson, M, Garner, P, Holgate, ST, David Howells, Karp, NA, Lazic, SE, Lidster, K, MacCallum, CJ, Macleod, M, Pearl, EJ, Petersen, OH, Rawle, F, Reynolds, P, Rooney, K, Sena, ES, Silberberg, SD, Steckler, T, Wurbel, H
Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting of animal research. They consist of a checklist of information to include in publications describing in vivo experiments to enable others to scrutinise the work adequately, evaluate its methodological rigour, and reproduce the methods and results. Despite considerable levels of endorsement by funders and journals over the years, adherence to the guidelines has been inconsistent, and the anticipated improvements in the quality of reporting in animal research publications have not been achieved. Here, we introduce ARRIVE 2.0. The guidelines have been updated and information reorganised to facilitate their use in practice. We used a Delphi exercise to prioritise and divide the items of the guidelines into 2 sets, the "ARRIVE Essential 10," which constitutes the minimum requirement, and the "Recommended Set," which describes the research context. This division facilitates improved reporting of animal research by supporting a stepwise approach to implementation. This helps journal editors and reviewers verify that the most important items are being reported in manuscripts. We have also developed the accompanying Explanation and Elaboration (E&E) document, which serves (1) to explain the rationale behind each item in the guidelines, (2) to clarify key concepts, and (3) to provide illustrative examples. We aim, through these changes, to help ensure that researchers, reviewers, and journal editors are better equipped to improve the rigour and transparency of the scientific process and thus reproducibility.

History

Publication title

PLoS Biology

Volume

18

Issue

7

Article number

e3000410

Number

e3000410

ISSN

1544-9173

Department/School

Tasmanian School of Medicine

Publisher

Public Library of Science

Place of publication

United States

Rights statement

Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 1.0 Universal (CC0 1.0) public domain dedication. (https://creativecommons.org/publicdomain/zero/1.0/)

Repository Status

  • Open

Socio-economic Objectives

Expanding knowledge in the health sciences

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC