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The Association of Early Life Supplemental Nutrition With Lean Body Mass and Grip Strength in Adulthood: Evidence From APCAPS

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posted on 2023-05-19, 03:41 authored by Kulkarni, B, Kuper, H, Radhakrishna, KV, Andrew HillsAndrew Hills, Nuala ByrneNuala Byrne, A Taylor, Sullivan, R, Bowen, L, Wells, JC, Ben-Shlomo, Y, Smith, GD, Ebrahim, S, Kinra, S
In the present study, we examined the associations of early nutrition with adult lean body mass (LBM) and muscle strength in a birth cohort that was established to assess the long-term impact of a nutrition program. Participants (n = 1,446, 32% female) were born near Hyderabad, India, in 29 villages from 1987 to 1990, during which time only intervention villages (n = 15) had a government program that offered balanced protein-calorie supplementation to pregnant women and children. Participants’ LBM and appendicular skeletal muscle mass were measured using dual energy x-ray absorptiometry; grip strength and information on lifestyle indicators, including diet and physical activity level, were also obtained. Ages (mean = 20.3 years) and body mass indexes (weight (kg)/height (m)2; mean = 19.5) of participants in 2 groups were similar. Current dietary energy intake was higher in the intervention group. Unadjusted LBM and grip strength were similar in 2 groups. After adjustment for potential confounders, the intervention group had lower LBM (β = −0.75; P = 0.03), appendicular skeletal muscle mass, and grip strength than did controls, but these differences were small in magnitude (<0.1 standard deviation). Multivariable regression analyses showed that current socioeconomic position, energy intake, and physical activity level had a positive association with adult LBM and muscle strength. This study could not detect a “programming” effect of early nutrition supplementation on adult LBM and muscle strength.

History

Publication title

American Journal of Epidemiology

Volume

179

Issue

6

Pagination

700-709

ISSN

0002-9262

Department/School

School of Health Sciences

Publisher

Oxford Univ Press Inc

Place of publication

United States

Rights statement

© The Author 2014. Licensed under Creative Commons Attribution 3.0 Unported (CC BY 3.0) http://creativecommons.org/licenses/by/3.0/

Repository Status

  • Open

Socio-economic Objectives

Nutrition

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