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The Immune Response of the Tasmanian Devil (Sarcophilus harrisii) and Devil Facial Tumour Disease
journal contributionposted on 2023-05-16, 21:21 authored by Gregory WoodsGregory Woods, Kreiss, A, Bekov, K, Siddle, HV, Obendorf, DL, Muller, HK
One of the most remarkable aspects of Devil Facial Tumour Disease (DFTD) is its infectious nature, and for successful transmission it must avoid detection by the devil's immune system. For this to occur, the devil either is severely immunosuppressed or factors produced by the tumor contribute to its avoidance of immune detection. An analysis of the devil's immune system revealed the presence of normal-looking lymphoid organs and lymphoid cells. At a functional level the lymphocytes proliferated in response to mitogen stimulation. Subcutaneous injection of a cellular antigen produced a strong antibody response, providing compelling evidence that the devil has a competent immune system. Tumor cell analysis demonstrated that the tumor expresses the genes of the major histocompatibility complex; however, there was a limited diversity. Therefore, the most likely explanation for devil-to-devil transmission of DFTD is that the tumor is not recognized by the devil as "non-self" because of the limited genetic diversity. With its consistent morphology and relatively stable genome, this tumor would provide a reasonable target for a vaccine approach, provided the immune system can be coaxed into recognizing the tumor as "non-self." Â© 2007 Ecohealth Journal Consortium.
Department/SchoolMenzies Institute for Medical Research
Place of publicationNew york USA