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The Trace of Non-classical Biogenic Amines: A New Road to Addiction Recovery
journal contributionposted on 2023-05-19, 11:18 authored by Canales, JJ
timulant abuse is prevalent according to recent global epidemiological studies. Research into treatment for problematic stimulant abuse has yet to find a suitable pharmacotherapeutic agent to assist with detoxification, withdrawal and relapse prevention. The newly discovered trace amine-associated receptor 1 (TAAR1) constitutes a novel receptor target for medication development with significant potential to treat the pathological changes produced by chronic drug exposure, especially stimulant abuse. Here, I briefly review evidence indicating that TAAR1 modulates the activity of the dopamine system and strongly influences the neurochemical and behavioral actions of psychomotor stimulants. The evidence discussed confirms the view that TAAR1 is a promising candidate receptor for the design of new effective addiction therapies.
Publication titleJournal of Addiction Research & Therapy
Department/SchoolSchool of Psychological Sciences
PublisherOmics Publishing Group
Place of publicationUnited States