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The acute phase response of plasma proteins in the polyprotodont marsupial Monodelphis domestica

journal contribution
posted on 2023-05-16, 11:09 authored by Richardson, SJ, Dziegielewska, KM, Andersen, NA, Frost, S, Schreiber, G
In eutherians, patterns of plasma protein levels in blood change during the acute phase response to trauma and inflammation. Until now, such an acute phase response has not been characterised in a noneutherian species. Here we describe the acute phase response in a marsupial species, the South American polyprotodont marsupial Monodelphis domestica, after brain surgery or injection of lipopolysaccharide. Several days after brain surgery, transthyretin was not detected in plasma. For 48 hr following injection of lipopolysaccharide, the concencration of haptoglobin in plasma increased, that of transthyretin decreased, and the concentration of albumin in plasma did not change significantly. The American polyprotodont marsupials are probably more closely related to the common ancestor marsupial than the Australian marsupials are. It is most likely that the transthyretin gene was not expressed in the liver of this common ancestor. As the transthyretin gene is expressed in the liver of M. domestica, it seems that as soon as transthyretin is synthesised by the liver, it is under negative acute phase control.


Publication title

Comparative Biochemistry and Physiology. B: Comparative Biochemistry








Tasmanian School of Medicine


Elsevier Science

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