University Of Tasmania
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The association of hepatocyte growth factor (HGF) gene with primary angle closure glaucoma in the Nepalese population

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journal contribution
posted on 2023-05-17, 23:50 authored by Awadalla, MS, Thapa, SS, Kathryn BurdonKathryn Burdon, Alexander HewittAlexander Hewitt, Craig, JE

Purpose: Genetic variation in the hepatocyte growth factor (HGF) gene has recently been associated with hyperopia, which is a known risk factor for primary angle closure glaucoma (PACG). This study aimed to investigate whether genetic variation in HGF is associated with primary angle closure glaucoma in the Nepalese population.

Methods: One hundred six Nepalese patients with primary angle closure glaucoma and 204 matched controls were recruited. Twelve tag single nucleotide polymorphisms (SNPs) were selected and genotyped to cover the majority of common variation within HGF. Genotype and haplotype analyses were conducted in PLINK.

Results: Four HGF SNPs were found to be significantly associated with PACG, rs5745718, rs12536657, rs12540393 and rs17427817 (p=0.002, 0.002, 0.0006, and 0.0006, respectively). In addition, haplotype analysis showed one common haplotype to be significantly associated with PACG (p=0.001) in this population.

Conclusions: Genetic variation in HGF is associated with PACG in the Nepalese population. Additional replication studies in other populations are necessary to confirm this association and to further explore the role of HGF in the pathogenesis of this blinding disease.


Publication title

Molecular Vision








Menzies Institute for Medical Research


Molecular Vision

Place of publication

Lab B, 5500 Emory Eye Center, 1327 Clifton Rd, N E, Atlanta, USA, Ga, 30322

Rights statement

Copyright 2011 Molecular Vision

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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