The association of oxidized high density lipoprotein and oxidized non-high density lipoprotein with the development of microalbuminuria in diabetic nephropathy

This study was undertaken to investigate the association of total lipid peroxides and oxidized HDL in the progression of microalbuminuria in diabetic nephropathy. Fifty-five patients with type 2 diabetes mellitus were recruited in this study and were divided into 2 main groups based on the presence of microalbuminuria, the first group (microalbuminuric group n = 31) had a microalbuminuria between 30-299 ug/mg. The second group (normoalbuminuric group, n = 29) had an albumin level less than 30 ug/mg. The two diabetic groups were compared to the control group (n = 37). The results of our study showed significant elevation in the levels of serum lipid profiles and lipid peroxidation markers in the microalbuminuric group compared to the normoalbuminuric group at P < 0.001. This was associated with significant changes in these markers between the normoalbuminuric group and the control group. In addition, there was also significant changes in the level of these markers in the microalbuminuric group compared to the normoalbuminuric group at P < 0.001. The current study illustrates that the presence of microalbuminuria in type 2 DM can be regarded as an index of increased cardiovascular vulnerability and a signal for vigorous efforts at correction of the known risk factors to avoid the progression of diabetic nephropathy.