University Of Tasmania

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The energy cost of the tonoplast futile sodium leak

journal contribution
posted on 2023-05-20, 09:29 authored by Sergey ShabalaSergey Shabala, Chen, G, Chen, ZH, Pottosin, I
Active removal of Na+ from the cytosol into the vacuole plays a critical role in salinity tissue tolerance, but another, often neglected component of this trait is Na+ retention in vacuoles. This retention is based on an efficient control of Na+‐permeable slow‐ and fast‐vacuolar channels that mediate the back‐leak of Na+ into cytosol and, if not regulated tightly, could result in a futile cycle. This Tansley insight summarizes our current knowledge of regulation of tonoplast Na+‐permeable channels and discusses the energy cost of vacuolar Na+ sequestration, under different scenarios. We also report on a phylogenetic and bioinformatic analysis of the plant two‐pore channel family and the difference in its structure and regulation between halophytes and glycophytes, in the context of salinity tolerance.


Publication title

New Phytologist








Tasmanian Institute of Agriculture (TIA)


Blackwell Publishing Ltd

Place of publication

9600 Garsington Rd, Oxford, England, Oxon, Ox4 2Dg

Rights statement

Copyright 2019 the authors

Repository Status

  • Restricted

Socio-economic Objectives

Other plant production and plant primary products not elsewhere classified