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The host microbiome and impact of tuberculosis chemotherapy
journal contribution
posted on 2023-05-19, 21:10 authored by O'Toole, R, Gautam, SSThe treatment of Mycobacterium tuberculosis infection is often viewed in isolation from other human microbial symbionts. Understandably, the clinical priority is eliminating active or latent tuberculosis (TB) in patients. With the increasing resolution of molecular biology technologies, it is becoming apparent that antibiotic treatment can perturb the homeostasis of the host microbiome. For example, dysbiosis of the gut microbiota has been associated with an increased risk of the development of asthma, obesity and diabetes. Therefore, fundamental questions include: Does TB chemotherapy cause disruption of the human microbiome and adverse effects in patients; and are there signature taxa of dysbiosis following TB treatment. In this review, we examine recent research on the detection of changes in the microbiome during antibiotic administration and discuss specific findings that relate to the impact of anti-tubercular chemotherapy.
History
Publication title
TuberculosisVolume
113Pagination
26-29ISSN
1472-9792Department/School
Tasmanian School of MedicinePublisher
Churchill LivingstonePlace of publication
Journal Production Dept, Robert Stevenson House, 1-3 Baxters Place, Leith Walk, Edinburgh, Scotland, Midlothian, Eh1 3AfRights statement
© 2018 Elsevier LtdRepository Status
- Restricted