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The immunomodulatory effects of levamisole on the nonspecific immune system of Atlantic salmon, Salmo salar L

journal contribution
posted on 2023-05-16, 12:08 authored by Findlay, VL, Munday, BL
Sea water-adapted Atlantic salmon, Salmo salar L., were given a 2-h bath in a 2.5 mg L -1 levamisole (as levamisole hydrochloride) solution in fresh-water. Following bathing, the fish were held in full salinity sea water for 2 weeks before being subjected to a number of immunological assays. Heightened activity of the nonspecific defence system was demonstrated by increases in phagocytic index, phagocytic capacity and phagocytic activity, increased levels of the reactive oxygen intermediate, superoxide anion, and an increased lytic activity of both the mucus and the serum. These results indicate that levamisole is effective in augmenting parts of the nonspecific defence system of Atlantic salmon. This is the first record of the use and efficacy of levamisole as an immunomodulator in Atlantic salmon.

History

Publication title

Journal of Fish Diseases

Volume

23

Issue

6

Pagination

369-378

ISSN

0140-7775

Department/School

Institute for Marine and Antarctic Studies

Publisher

Blackwell Science Ltd

Place of publication

Oxford, England

Repository Status

  • Restricted

Socio-economic Objectives

Fisheries - aquaculture not elsewhere classified

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