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The immunomodulatory effects of levamisole on the nonspecific immune system of Atlantic salmon, Salmo salar L
journal contributionposted on 2023-05-16, 12:08 authored by Findlay, VL, Munday, BL
Sea water-adapted Atlantic salmon, Salmo salar L., were given a 2-h bath in a 2.5 mg L -1 levamisole (as levamisole hydrochloride) solution in fresh-water. Following bathing, the fish were held in full salinity sea water for 2 weeks before being subjected to a number of immunological assays. Heightened activity of the nonspecific defence system was demonstrated by increases in phagocytic index, phagocytic capacity and phagocytic activity, increased levels of the reactive oxygen intermediate, superoxide anion, and an increased lytic activity of both the mucus and the serum. These results indicate that levamisole is effective in augmenting parts of the nonspecific defence system of Atlantic salmon. This is the first record of the use and efficacy of levamisole as an immunomodulator in Atlantic salmon.
Publication titleJournal of Fish Diseases
Department/SchoolInstitute for Marine and Antarctic Studies
PublisherBlackwell Science Ltd
Place of publicationOxford, England