University Of Tasmania
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The impact of adherence and instillation proficiency of topical glaucoma medications on intraocular pressure

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journal contribution
posted on 2023-05-21, 01:38 authored by Tesfay Mehari Atey, Shibeshi, W, Giorgis, AT, Asgedom, SW

Background: The possible sequel of poorly controlled intraocular pressure (IOP) includes treatment failure, unnecessary medication use, and economic burden on patients with glaucoma.

Objective: To assess the impact of adherence and instillation technique on IOP control.

Methods: A cross-sectional study was conducted on 359 glaucoma patients in Menelik II Hospital from June 1 to July 31, 2015. After conducting a Q-Q analysis, multiple binary logistic analyses, linear regression analyses, and two-tailed paired t-test were conducted to compare IOP in the baseline versus current measurements.

Results: Intraocular pressure was controlled in 59.6% of the patients and was relatively well controlled during the study period (mean (M) = 17.911 mmHg, standard deviation (S) = 0.323) compared to the baseline (M = 20.866 mmHg, S = 0.383, t (358) = -6.70, p < 0.0001). A unit increase in the administration technique score resulted in a 0.272 mmHg decrease in IOP (p = 0.03). Moreover, primary angle-closure glaucoma (adjusted odds ratio (AOR) = 0.347, 95% confidence interval (CI): 0.144-0.836) and two medications (AOR = 1.869, 95% CI: 1.259-9.379) were factors affecting IOP.

Conclusion: Good instillation technique of the medications was correlated with a reduction in IOP. Consequently, regular assessment of the instillation technique and IOP should be done for better management of the disease.


Publication title

Journal of Ophthalmology

Article number









School of Pharmacy and Pharmacology


Hindawi Publishing Corporation

Place of publication

United States

Rights statement

Copyright 2017 Tesfay Mehari Atey et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

Repository Status

  • Open

Socio-economic Objectives

Human pharmaceutical treatments