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The oxidation of pyrrole
journal contribution
posted on 2023-05-18, 19:50 authored by Howard, J, Rihak, KJ, Alexander BissemberAlexander Bissember, Jason SmithJason SmithThe dearomatization of heterocycles has been a powerful means for producing functional molecules in synthesis. In the case of pyrroles, reductive methods (such as the Birch reduction) have been most widely exploited, while oxidative methods are generally dismissed as too difficult or unpredictable to be useful. However, since the early twentieth century considerable research has been carried out on the controlled oxidation of pyrroles to give highly functionalized products, using a variety of oxidants. This review presents a summary of all work up until the present day in the area of pyrrole oxidation, looking at the use of peroxide, singlet oxygen, hypervalent iodine reagents, a range or organic and inorganic oxidants, and electrochemical approaches. It also offers some perspective on the potential future role of pyrrole oxidation in synthesis.
History
Publication title
Chemistry - An Asian JournalVolume
11Pagination
155-167ISSN
1861-4728Department/School
School of Natural SciencesPublisher
Wiley - V C H Verlag GmbH & Co. KGaAPlace of publication
GermanyRights statement
Copyright 2016 Wiley-VCH Verlag GmbH & Co. KGaA, WeinheimRepository Status
- Restricted