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The pathophysiological effects of serum copper in type 2 diabetes mellitus with and without diabetic nephropathy

journal contribution
posted on 2023-05-18, 07:53 authored by Al-Bayati, MA, Jamil, DA, Al-Aubaidy, HA
This study was undertaken to investigate the effects of copper on the development of lipid peroxidation in patients with type 2 diabetes mellitus with and without diabetic nephropathy. Fifty-five patients with type 2 diabetes mellitus were recruited in this study and were divided into 2 sub-groups based on the presence of microalbuminuria, the first group (microalbuminuric group n = 31) had a microalbuminuria between 30-299 ug/mg. The second group (normoalbuminuric group, n = 29) had an albumin level less than 30 ug/mg. The two diabetic groups were compared to the control group (n = 37). The results of our study showed significant elevation in the levels of serum lipid profiles and lipid peroxidation markers in the microalbuminuric group compared to the normoalbuminuric group at P < 0.001. This was associated with significant rise of serum copper in the diabetic group with nephropathy compared to the diabetic group with no nephropathy and the control group, P < 0.001. The current study illustrates that the presence of microalbuminuria in type 2 DM can be regarded as an index of increased cardiovascular vulnerability and a signal for vigorous efforts at correction of known modifiable risk factors in which serum Cu one of them.


Publication title

World Journal of Pharmaceutical Research








Tasmanian School of Medicine


World Journal of Pharmaceutical Research

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Copyright 2015 World Journal of Pharmaceutical Research

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Clinical health not elsewhere classified

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