University Of Tasmania

File(s) under permanent embargo

The potential roles of genetic factors in predicting ageing-related cognitive change and Alzheimer's disease

journal contribution
posted on 2023-05-21, 02:40 authored by Pan, G, Anna KingAnna King, Feitong WuFeitong Wu, Steve Simpson JRSteve Simpson JR, Adele WoodhouseAdele Woodhouse, Phipps, A, James VickersJames Vickers
Alzheimer's disease (AD) is a complex neurological disorder of uncertain aetiology, although substantial research has been conducted to explore important factors related to risk of onset and progression. Both lifestyle (e.g., complex mental stimulation, vascular health) and genetic factors (e.g., APOE, BDNF, PICALM, CLU, APP, PSEN1, PSEN2, and other genes) have been associated with AD risk. Despite more than thirty years of genetic research, much of the heritability of AD is not explained by measured loci. This suggests that the missing heritability of AD might be potentially related to rare variants, gene-environment and gene-gene interactions, and potentially epigenetic modulators. Moreover, while ageing is the most substantial factor risk for AD, there are limited longitudinal studies examining the association of genetic factors with decline in cognitive function due to ageing and the preclinical stages of this condition. This review summarises findings from currently available research on the genetic factors of ageing-related cognitive change and AD and suggests some future research directions.


Publication title

Ageing Research Reviews








Tasmanian School of Medicine


Elsevier Science

Place of publication

United Kingdom

Rights statement

© 2021 Published by Elsevier B.V.

Repository Status

  • Restricted

Socio-economic Objectives

Diagnosis of human diseases and conditions