The role of host genetics in leishmaniasis
journal contribution
posted on 2023-05-17, 01:07 authored by Sakthianandeswaren, A, Simon James FooteSimon James Foote, Handman, ELeishmaniasis is one of the world's important infectious diseases. It is prevalent in tropical and subtropical regions of the world and endemic in 88 countries, with two million new cases of leishmaniasis reported annually. As a complex disease, the pathology of leishmaniasis varies and is determined by factors such as the environment, the insect vector, and parasite and host genetics. The contributing host genetics involve multiple genes; thus, the mouse model of leishmaniasis has been exploited extensively in an attempt to identify and dissect the contribution of disease modifier genes to pathogenesis. This review summarizes recent advances in the identification of genetic loci involved in the host response to Leishmania spp. in the mouse model and in the human situation. Crown Copyright © 2009.
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Publication title
Trends in ParasitologyVolume
25Issue
8Pagination
383-391ISSN
1471-4922Department/School
Menzies Institute for Medical ResearchPublisher
Elsevier Sci LtdPlace of publication
The Boulevard, Langford Lane, Kidlington, Oxford, England, Oxon, Ox5 1GbRepository Status
- Restricted
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