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The role of macrophages in allograft rejection

journal contribution
posted on 2023-05-17, 23:46 authored by Wyburn, KR, Matthew JoseMatthew Jose, Wu, H, Atkins, RC, Chadban, SJ
Macrophage accumulation has long been recognized as a feature of allograft rejection, yet the role of macrophages in rejection remains underappreciated. Macrophages contribute to both the innate and acquired arms of the alloimmune response and thus may be involved in all aspects of acute and chronic allograft rejection. Recent advances in macrophage biology have allowed a better understanding of the mechanisms of macrophage accumulation, their state of activation and the pleuripotent roles they play in allograft rejection. Therapeutic attention to macrophages, in addition to T lymphocytes, may lead to improved outcomes in organ transplantation.

History

Publication title

Transplantation

Volume

80

Issue

12

Pagination

1641-7

ISSN

0041-1337

Department/School

Tasmanian School of Medicine

Publisher

Lippincott Williams & Wilkins

Place of publication

530 Walnut St, Philadelphia, USA, Pa, 19106-3621

Rights statement

Copyright 2005 Lippincott Williams & Wilkins

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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