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The utilization of antithrombotic therapy in older Australians with atrial fibrillation

journal contribution
posted on 2023-05-18, 18:04 authored by Bridget FrainBridget Frain, Ronald CastelinoRonald Castelino, Luke BereznickiLuke Bereznicki

What is known and Objective: Oral anticoagulants are essential drugs for the prevention of thromboembolic events in patients with atrial fibrillation (AF). Anticoagulants are, however, commonly withheld due to a perceived risk of severe adverse events. The underutilization of anticoagulants in patients with AF has been demonstrated internationally, but to date, there are limited data available in the Australian context. The aim of this study was to determine the utilization patterns of anticoagulants (including novel oral anticoagulants) with respect to stroke and bleeding risk among patients with AF within the community.

Methods: We performed a nonexperimental, retrospective analysis designed to evaluate antithrombotic usage for AF in Australia. The utilization of antithrombotic therapy and the appropriateness of therapy were determined based on CHADS2, CHA2DS2-VASc and HAS-BLED risk stratification schemes. D risk stratification schemes. The presence of documented contraindications was used to determine the appropriateness of antithrombotic therapy.

What is new and Conclusion: Anticoagulants were overutilized in patients at low risk of stroke and underutilized in patients at higher risk of stroke. As the HAS-BLED score increased, the likelihood of patients receiving an anticoagulant decreased regardless of CHADS2 or CHA2DS2-VASc scores.


Publication title

Clinical and Applied Thrombosis/Hemostasis










School of Pharmacy and Pharmacology


Westminster Publ Inc

Place of publication

United States

Rights statement

Copyright 2016 The Authors

Repository Status

  • Restricted

Socio-economic Objectives

Other health not elsewhere classified

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