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The wound repair response controls outcome to cutaneous leishmaniasis

journal contribution
posted on 2023-05-16, 20:26 authored by Sakthianandeswaren, A, Elso, CM, Simpson, K, Curtis, JM, Kumar, B, Speed, TP, Handman, E, Simon James FooteSimon James Foote
Chronic microbial infections are associated with fibrotic and inflammatory reactions known as granulomas showing similarities to wound-healing and tissue repair processes. We have previously mapped three leishmaniasis susceptibility loci, designated lmr1. -2, and -3, which exert their effect independently of T cell immune responses. Here, we show that the wound repair response is critically important for the rapid cure in murine cutaneous leishmaniasis caused by Leishmania major. Mice congenic for leishmaniasis resistance loci, which cured their lesions more rapidly than their susceptible parents, also expressed differentially genes involved in tissue repair, laid down more ordered collagen fibers, and healed punch biopsy wounds more rapidly. Fibroblast monolayers from these mice repaired in vitro wounds faster, and this process was accelerated by supernatants from infected macrophages. Because these effects are independent of T cell-mediated immunity, we conclude that the rate of wound healing is likely to be an important component of innate immunity involved in resistance to cutaneous leishmaniasis. © 2005 by The National Academy of Sciences of the USA.


Publication title

Proceedings of the National Academy of Sciences of the United States of America










Menzies Institute for Medical Research


Natl Acad Sciences

Place of publication

2101 Constitution Ave Nw, Washington, USA, Dc, 20418

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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