File(s) under permanent embargo
Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: An Australian and New Zealand perspective Part 2 New and emerging therapies and their efficacy
journal contributionposted on 2023-05-18, 02:12 authored by Broadley, SA, Barnett, MH, Boggild, M, Brew, BJ, Butzkueven, H, Heard, R, Hodgkinson, S, Kermode, AG, Lechner-Scott, J, Macdonell, RAL, Marriott, M, Mason, DF, Parratt, J, Reddel, SW, Shaw, CP, Slee, M, Spies, J, Bruce TaylorBruce Taylor, Carroll, WM, Kilpatrick, TJ, King, J, McCombe, PA, Pollard, JD, Willoughby, E
In Part 2 of this three part review of multiple sclerosis (MS) treatment with a particular focus on the Australian and New Zealand perspective, we review the newer therapies that have recently become available and emerging therapies that have now completed phase III clinical trial programs. We go on to compare the relative efficacies of these newer and emerging therapies alongside the existing therapies. The effectiveness of Î²-interferon in the treatment of different stages and the different disease courses of MS is critically reviewed with the conclusion that the absolute level of response in term of annualised relapse rates (where relapses occur) and MRI activity are similar, but are disappointing in terms of sustained disability progression for progressive forms of the disease. Finally we review the controversial area of combination therapy for MS. Whilst it remains the case that we have no cure or means of preventing MS, we do have a range of effective therapies that when used appropriately and early in the disease course can have a significant impact on short term and longer term outcomes. Crown Copyright Â© 2014.
Publication titleJournal of Clinical Neuroscience
Department/SchoolMenzies Institute for Medical Research
Place of publicationJournal Production Dept, Robert Stevenson House, 1-3 Baxters Place, Leith Walk, Edinburgh, Scotland, Midlothian, Eh1 3Af
Rights statementCopyright 2014 Elsevier