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Therapeutic potential of enoxaparin in lichen planus: exploring reasons for inconsistent reports

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posted on 2023-05-19, 19:26 authored by Rahul PatelRahul Patel, Madhur ShastriMadhur Shastri, Ming, LC, Syed Razi ZaidiSyed Razi Zaidi, Gregory PetersonGregory Peterson
Lichen planus (LP) is an uncommon mucocutaneous inflammatory condition, that is immunologically mediated, typically pruritic and often recurs. The currently advocated therapies are either not highly effective or associated with severe side effects. Enoxaparin, a widely used anticoagulant, is composed of both anticoagulant and non-anticoagulant fragments. Enoxaparin is reported to have anti-inflammatory properties and it was found to be effective in LP. However, the results from clinical studies have varied substantially and, therefore, the clinical role of enoxaparin in LP remains uncertain. This review focuses on potential reasons for the reported inconsistent outcomes, as well as proposing solutions; these include identifying batch-to-batch inconsistency in the composition of enoxaparin. The potential therapeutic value of enoxaparin in LP must be explored using well-designed clinical trials, combined with experimental studies that focus on identifying the anti-inflammatory fragments of enoxaparin and elucidating the mechanism of action of these non-anticoagulant fragments.

History

Publication title

Frontiers in Pharmacology

Volume

9

Article number

586

Number

586

Pagination

1-10

ISSN

1663-9812

Department/School

School of Pharmacy and Pharmacology

Publisher

Frontiers Research Foundation

Place of publication

Switzerland

Rights statement

Copyright 2018 Patel, Shastri, Ming, Zaidi and Peterson. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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