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Thrombosis in Systemic Lupus Erythematosus
journal contribution
posted on 2023-05-17, 01:28 authored by Palatinus, AA, Adams, MJSystemic lupus erythematosus (SLE) is a potentially fatal multiorgan inflammatory disease that primarily affects females. Due to the heterogeneity of clinical manifestations and lack of laboratory tests that are both specific and sensitive for the disease, diagnosis of SLE can often be difficult. Although the precise etiology remains to be fully elucidated, it is probable that various environmental, genetic, and hormonal factors contribute to the development of the disease. Patients with SLE have an increased risk for premature thrombosis and/or atherosclerosis, with up to half experiencing a thrombotic event. Furthermore, antiphospholipid antibodies probably play a key role in the development of thrombosis by affecting various hemostatic protein interactions with phospholipids and cell surfaces as well as platelet function. Despite recent advances in knowledge related to the factors that contribute to the pathophysiology of SLE, numerous challenges related to earlier diagnosis as well as the prediction and prevention of thrombotic events remain to be fully addressed.
History
Publication title
Seminars in Thrombosis and HaemostasisVolume
35Issue
7Pagination
621-629ISSN
0094-6176Department/School
School of Health SciencesPublisher
Thieme Medical PublishersPlace of publication
New York, USARights statement
Copyright © 2009 Thieme Medical PublishersRepository Status
- Restricted