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Timing-specific effects of single-session M1 anodal tDCS on motor sequence retention in healthy older adults

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posted on 2023-05-20, 22:59 authored by Rohan PuriRohan Puri, Mark HinderMark Hinder, Kruger, M, Jeffery SummersJeffery Summers
Anodal transcranial direct current stimulation (tDCS) may assist in counteracting age-related decline in cognitive and motor functions. The current study investigated the potential impact of anodal tDCS, and the timing of its application, in mitigating age-related deficits in motor sequence learning.

Forty-eight healthy older adults received, over the primary motor cortex (M1), tDCS – anodal and sham at least 1 week apart – before, during or after an explicit sequence-learning task with electrophysiological measures of corticospinal excitability (CSE) and short-interval intracortical inhibition (SICI) also obtained.

Bayesian analyses revealed no generalised benefit of anodal tDCS to motor acquisition and immediate retention. Furthermore, there was not enough evidence to support timing-specific stimulation differences on performance during acquisition and immediate retention. However, performance at delayed retention – measured 24 ​h after acquisition – was worse in the anodal (13.1%) than sham (17.6%) tDCS session for the group receiving tDCS during sequence acquisition, but not before (anodal: 18.4%; sham: 16.7%) or after (anodal: 18.5%; sham: 16.3%) it. No corresponding task-specific stimulation-based changes in CSE and SICI were observed.

Thus, single-session M1 anodal tDCS in healthy older adults not only proved ineffective in facilitating sequence acquisition and immediate retention but also, when administered during sequence learning, proved detrimental to delayed retention. Overall, these null and negative results may have implications for the use of tDCS in clinical and rehabilitative settings, especially in the elderly.

History

Publication title

Neuroimage

Article number

100009

Number

100009

ISSN

1053-8119

Department/School

Marketing

Publisher

Academic Press Inc Elsevier Science

Place of publication

525 B St, Ste 1900, San Diego, USA, Ca, 92101-4495

Rights statement

Copyright 2021 the authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

Repository Status

  • Open

Socio-economic Objectives

Health related to ageing

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