University Of Tasmania
134343 - Tiredness in acute and chronic depression treated with transcranial magnetic stimulation.pdf (173.16 kB)
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Tiredness in acute and chronic depression treated with transcranial magnetic stimulation

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journal contribution
posted on 2023-05-20, 06:12 authored by Saxby PridmoreSaxby Pridmore, Erger, S, Rybak, M, May, T

Background: Tiredness is used in some characterizations of major depressive disorder (MDD). Transcranial magnetic stimulation (TMS) lowers all symptoms of MDD.

Objective: To explore whether, 1) a visual analogue scale (VAS) for tiredness is a valid and reliable measure of a feature of MDD, and 2) TMS treatment reduces subjective tiredness occurring in MDD.

Method: A naturalistic study of treatment with 10 Hz TMS. Completed pre- and post-treatment: HAMD-6, a visual analogue scale (VAS-6), the Clinical Global Impression – Severity (CGI-S) and a ‘VAS-tiredness’. Two groups received TMS. Acute course: N=52 participants suffering acute MDD, received 20 treatment courses (total courses 86). Relapse prevention (RP) course: N=26 participants suffering chronic relapsing MDD received scheduled episodic courses over 3 days; (total courses 266). VAS-tiredness scores were compared with the standardized tool results.

Results: There were significant medium to large correlations between pre- and post-treatment VAS-tiredness and the standard depression measures (HAMD-6 .406 to .447, VAS-6 .446 to .525, CGI-S .348 to .407; all p<.001). TMS treatment produced a significant reduction in VAS tiredness in both (Acute course and RP) groups (main effect: F(1,350)=147.3, p<.001, η2=.30). The two groups displayed difference in the pre-treatment VAStiredness with the Acute group having higher scores pre-treatment. Post-treatment tiredness scores were similar.

Conclusion: -tiredness is a valid measure of a feature of MDD. VAS-tiredness provides potentially useful information and complements standard mood tools. TMS treatment can reduce tiredness in MDD.


Publication title

American Journal of Medical Research








Tasmanian School of Medicine


Addleton Academic Publishers

Place of publication

United States

Rights statement

Copyright 2019 Addleton Academic Publishers

Repository Status

  • Open

Socio-economic Objectives

Mental health

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