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Traffic-related air pollution exposure over a 5-year period is associated with increased risk of asthma and poor lung function in middle age

journal contribution
posted on 2023-05-19, 13:58 authored by Bowatte, G, Erbas, B, Lodge, CJ, Knibbs, LD, Gurrin, LC, Marks, GB, Thomas, PS, Johns, DP, Giles, GG, Hui, J, Dennekamp, M, Perret, JL, Abramson, MJ, Walters, EH, Matheson, MC, Dharmage, SC
Current evidence concerning the impact of exposure to traffic-related air pollution (TRAP) on adult respiratory morbidity mainly comes from cross-sectional studies. We sought to establish more robust measures of this association and potential gene-environment interactions using longitudinal data from an established cohort study.Associations between measures of TRAP (nitrogen dioxide (NO2) and distance to major roads) and wheeze, asthma prevalence and lung function were investigated in participants of the Tasmanian Longitudinal Health Study at 45- and 50-year follow-ups. Generalised estimating equations were used to quantify associations and the potential modifying effect of glutathione S-transferase gene variants.Living <200 m from a major road was associated with increased prevalence of current asthma and wheeze, and lower lung function. The association between living <200 m from a major road and current asthma and wheeze was more marked for carriers of the GSTT1 null and GSTP1 val/val or ile/val genotypes. Over the 5-year period, higher NO2 exposures were associated with increased current asthma prevalence. Higher NO2 exposure was associated with lower forced vital capacity for carriers of the GSTT1 null genotype.TRAP exposures were associated with increased risk of asthma, wheeze and lower lung function in middle-aged adults. The interaction with the GSTT1 genotype suggests that deficient antioxidant mechanisms may play a role in these adverse health effects.

History

Publication title

European Respiratory Journal

Volume

50

Issue

4

Pagination

1-11

ISSN

0903-1936

Department/School

Tasmanian School of Medicine

Publisher

European Respiratory Society

Place of publication

United Kingdom

Rights statement

Copyright © ERS 2017

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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