University Of Tasmania
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Transcriptomic profiling of fibropapillomatosis in green sea turtles (Chelonia mydas) from south Texas

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posted on 2023-05-20, 23:53 authored by Nicholas BlackburnNicholas Blackburn, Leandro, AC, Nahvi, N, Devlin, MA, Leandro, M, Martinez Escobedo, I, Peralta Fernandez, JM, George, J, Stacy, BA, deMaar, TW, Blangero, J, Keniry, M, Curran, JE
Sea turtle fibropapillomatosis (FP) is a tumor promoting disease that is one of several threats globally to endangered sea turtle populations. The prevalence of FP is highest in green sea turtle (Chelonia mydas) populations, and historically has shown considerable temporal growth. FP tumors can significantly affect the ability of turtles to forage for food and avoid predation and can grow to debilitating sizes. In the current study, based in South Texas, we have applied transcriptome sequencing to FP tumors and healthy control tissue to study the gene expression profiles of FP. By identifying differentially expressed turtle genes in FP, and matching these genes to their closest human ortholog we draw on the wealth of human based knowledge, specifically human cancer, to identify new insights into the biology of sea turtle FP. We show that several genes aberrantly expressed in FP tumors have known tumor promoting biology in humans, including CTHRC1 and NLRC5, and provide support that disruption of the Wnt signaling pathway is a feature of FP. Further, we profiled the expression of current targets of immune checkpoint inhibitors from human oncology in FP tumors and identified potential candidates for future studies.


Publication title

Frontiers in Immunology








Menzies Institute for Medical Research


Frontiers Research Foundation

Place of publication


Rights statement

Copyright © 2021 Blackburn, Leandro, Nahvi, Devlin, Leandro, Martinez Escobedo, Peralta, George, Stacy, deMaar, Blangero, Keniry and Curran. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License (

Repository Status

  • Open

Socio-economic Objectives

Marine biodiversity; Expanding knowledge in the biological sciences