University Of Tasmania
106003 journal article.pdf (1.17 MB)

Transdiagnostic versus disorder-specific and clinician-guided versus self-guided internet-delivered treatment for generalized anxiety disorder and comorbid disorders: A randomized controlled trial

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journal contribution
posted on 2023-05-18, 16:17 authored by Dear, BF, Staples, LG, Terides, MD, Karin, E, Zou, J, Johnston, L, Gandy, M, Fogliati, VJ, Wootton, BM, McEvoy, PM, Titov, N
Generalized anxiety disorder (GAD) can be treated effectively with either disorder-specific cognitive behavior therapy (DS-CBT) or transdiagnostic CBT (TD-CBT). The relative benefits of DS-CBT and TD-CBT for GAD and the relative benefits of delivering treatment in clinician guided (CG-CBT) and self-guided (SG-CBT) formats have not been examined. Participants with GAD (n = 338) were randomly allocated to receive an internet-delivered TD-CBT or DS-CBT intervention delivered in either CG-CBT or SG-CBT formats. Large reductions in symptoms of GAD (Cohen’s d ≥ 1.48; avg. reduction ≥ 50%) and comorbid major depressive disorder (Cohen’s d ≥ 1.64; avg. reduction ≥ 45%), social anxiety disorder (Cohen’s d ≥ 0.80; avg. reduction ≥ 29%) and panic disorder (Cohen’s d ≥ 0.55; avg. reduction ≥ 33%) were found across the conditions. No substantive differences were observed between DS-CBT and TD-CBT or CG-CBT and SG-CBT, highlighting the public health potential of carefully developed TD-CBT and SG-CBT.


Publication title

Journal of Anxiety Disorders








School of Psychological Sciences


Pergamon-Elsevier Science Ltd

Place of publication

United Kingdom

Rights statement

Copyright 2015 The Authors Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

Repository Status

  • Open

Socio-economic Objectives

Mental health