File(s) under permanent embargo
Translation of animal endocannabinoid models of PTSD mechanisms to humans: where to next?
journal contributionposted on 2023-05-21, 05:08 authored by Ney, LJ, Crombie, KM, Mayo, LM, Felmingham, KL, Bowser, T, Allison MatthewsAllison Matthews
The endocannabinoid system is known to be involved in mechanisms relevant to PTSD aetiology and maintenance, though this understanding is mostly based on animal models of the disorder. Here we review how human paradigms can successfully translate animal findings to human subjects, with the view that substantially increased insight into the effect of endocannabinoid signalling on stress responding, emotional and intrusive memories, and fear extinction can be gained using modern paradigms and methods for assessing the state of the endocannabinoid system in PTSD.
Publication titleNeuroscience and Biobehavioral Reviews
Department/SchoolSchool of Psychological Sciences
PublisherPergamon-Elsevier Science Ltd
Place of publicationThe Boulevard, Langford Lane, Kidlington, Oxford, England, Ox5 1Gb
Rights statement© 2021 Elsevier Ltd. All rights reserved.