Translation of animal endocannabinoid models of PTSD mechanisms to humans: where to next?
journal contribution
posted on 2023-05-21, 05:08authored byNey, LJ, Crombie, KM, Mayo, LM, Felmingham, KL, Bowser, T, Allison MatthewsAllison Matthews
The endocannabinoid system is known to be involved in mechanisms relevant to PTSD aetiology and maintenance, though this understanding is mostly based on animal models of the disorder. Here we review how human paradigms can successfully translate animal findings to human subjects, with the view that substantially increased insight into the effect of endocannabinoid signalling on stress responding, emotional and intrusive memories, and fear extinction can be gained using modern paradigms and methods for assessing the state of the endocannabinoid system in PTSD.
History
Publication title
Neuroscience and Biobehavioral Reviews
Volume
132
Pagination
76-91
ISSN
0149-7634
Department/School
School of Psychological Sciences
Publisher
Pergamon-Elsevier Science Ltd
Place of publication
The Boulevard, Langford Lane, Kidlington, Oxford, England, Ox5 1Gb