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Translation of animal endocannabinoid models of PTSD mechanisms to humans: where to next?

journal contribution
posted on 2023-05-21, 05:08 authored by Ney, LJ, Crombie, KM, Mayo, LM, Felmingham, KL, Bowser, T, Allison MatthewsAllison Matthews
The endocannabinoid system is known to be involved in mechanisms relevant to PTSD aetiology and maintenance, though this understanding is mostly based on animal models of the disorder. Here we review how human paradigms can successfully translate animal findings to human subjects, with the view that substantially increased insight into the effect of endocannabinoid signalling on stress responding, emotional and intrusive memories, and fear extinction can be gained using modern paradigms and methods for assessing the state of the endocannabinoid system in PTSD.

History

Publication title

Neuroscience and Biobehavioral Reviews

Volume

132

Pagination

76-91

ISSN

0149-7634

Department/School

School of Psychological Sciences

Publisher

Pergamon-Elsevier Science Ltd

Place of publication

The Boulevard, Langford Lane, Kidlington, Oxford, England, Ox5 1Gb

Rights statement

© 2021 Elsevier Ltd. All rights reserved.

Repository Status

  • Restricted

Socio-economic Objectives

Mental health; Expanding knowledge in psychology

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