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Trimetazidine attenuates the acute inflammatory response induced by Novolimus eluting bioresorbable coronary scaffold implantation
Background: This study aims to investigate the inflammatory response in Novolimus bioresorbable coronary scaffold implantation after a course treatment with trimetazidine (35 mg tablet/twice daily for 4 days).
Methods: This was a randomized single blind study. Forty diabetic patients with critical coronary stenosis were subjected to elective coronary scaffold implantation in Al-Najaf Center for Cardiac Surgery and Trans-Catheter Therapy, Najaf, Iraq, between January and July 2015. All patients were informed about the nature of the study and they signed the consent form before they included in the study. Patients were randomly allocated into the two study groups: Group 1 included 20 patients who did the elective coronary scaffold implementation without trimetazidine medication. Group 2 included 20 patients who did the elective coronary scaffold implementation with a course of the trimetazidine (35 mg tablet/twice daily for 4 days).
Results: There were significant reduction in the levels of the interleukin-6 and cardiac troponin-I in the trimetazidine-treated group (group 2) compared to the control group (group 1) (P < 0.001), after 12 h and 24 h post-operative. This was associated with a significant rise in the levels of interleukin 10 in group 2 compared to group 1 (P < 0.001). Pentraxin-3 was significantly reduced in group 2 but only 24 h post-operative (P < 0.006).
Conclusion: Our study concluded that trimetazidine minimizes the acute inflammatory response occurred due to systemic release of inflammatory markers into blood in diabetic patients undergoing elective Novolimus bioresorbable coronary scaffold implementation.
Publication titleInternational Journal of Cardiology
Department/SchoolTasmanian School of Medicine
PublisherElsevier Sci Ireland Ltd
Place of publicationIreland
Rights statementCopyright 2016 Elsevier Ireland Ltd.