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Tumor necrosis factor negative bone marrow-derived dendritic cells exhibit deficient IL-10 expression

journal contribution
posted on 2023-05-17, 05:08 authored by Roomberg, A, Kling, J, Fromm, P, Heinrich KornerHeinrich Korner
The effective maturation of dendritic cells (DC) is complex and highly regulated and requires the presence of a variety of signals. Tumor necrosis factor (TNF) and its receptors or innate pattern recognition receptors such as the toll-like receptors have been shown to contribute to this process. DC derived from bone marrow cells in the presence of granulocyte/macrophage colony-stimulating factor can be used as a model to ascertain the contribution of different signals to DC maturation. Analysis of DC activated by addition of the mycobacterial vaccine strain Bacillus Calmette-Gue rin showed that of the effector molecules studied only interleukin-10 expression was significantly reduced in TNF-negative (B6.TNF-/-) DC. Another effector molecule produced by DC, inducible nitric oxide synthase, was largely unchanged.

History

Publication title

Immunology and Cell Biology

Volume

88

Issue

8

Pagination

842-845

ISSN

0818-9641

Department/School

Menzies Institute for Medical Research

Publisher

Blackwell Publishing Asia

Place of publication

54 University St, P O Box 378, Carlton, Australia, Victoria, 3053

Rights statement

The definitive published version is available online at: http://onlinelibrary.wiley.com/

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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