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Type-2 Diabetes as a risk factor for severe COVID-19 infection

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posted on 2023-05-21, 00:39 authored by Norouzi, M, Norouzi, S, Ruggiero, A, Khan, MS, Stephen MyersStephen Myers, Kylie KavanaghKylie Kavanagh, Vemuri, R
The current outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), termed coronavirus disease 2019 (COVID-19), has generated a notable challenge for diabetic patients. Overall, people with diabetes have a higher risk of developing different infectious diseases and demonstrate increased mortality. Type 2 diabetes mellitus (T2DM) is a significant risk factor for COVID-19 progression and its severity, poor prognosis, and increased mortality. How diabetes contributes to COVID-19 severity is unclear; however, it may be correlated with the effects of hyperglycemia on systemic inflammatory responses and immune system dysfunction. Using the envelope spike glycoprotein SARS-CoV-2, COVID-19 binds to angiotensin-converting enzyme 2 (ACE2) receptors, a key protein expressed in metabolic organs and tissues such as pancreatic islets. Therefore, it has been suggested that diabetic patients are more susceptible to severe SARS-CoV-2 infections, as glucose metabolism impairments complicate the pathophysiology of COVID-19 disease in these patients. In this review, we provide insight into the COVID-19 disease complications relevant to diabetes and try to focus on the present data and growing concepts surrounding SARS-CoV-2 infections in T2DM patients.

History

Publication title

Microorganisms

Volume

9

Issue

6

Article number

1211

Number

1211

Pagination

1-17

ISSN

2076-2607

Department/School

School of Health Sciences

Publisher

MDPI AG

Place of publication

Switzerland

Rights statement

Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) License, (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Repository Status

  • Open

Socio-economic Objectives

Diagnosis of human diseases and conditions

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