University Of Tasmania

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Ultrastructural integrity of human capsulotomies created by a thermal device

journal contribution
posted on 2023-05-20, 01:12 authored by Hooshmand, J, Abell, RG, Karsten GoemannKarsten Goemann, Davies, PEJ, Brendan VoteBrendan Vote
Purpose: To investigate the ultrastructural features of anterior capsulotomy performed with a thermal device, the precision pulse capsulotomy (PPC).

Design: Prospective, multicenter case series.

Participants: Consecutive patients undergoing capsulotomy with the PPC device.

Methods: Prospective study of patients undergoing capsulotomy with the PPC by 2 surgeons, followed up by routine phacoemulsification cataract surgery, was undertaken. All capsulotomy specimens were collected for scanning electron microscopy (SEM). Observations were made regarding uniformity of the capsular edge and the presence of irregularities that may compromise integrity. Comparisons were made with manual continuous curvilinear capsulorrhexis.

Main Outcome Measures: Ultrastructural features of PPC and presence of irregularities.

Results: Frayed appearance of the anterior capsule edge was noted in postoperative visits under slit-lamp examination. Scanning electron microscopy sampling showed a generally uniform rolled capsular edge, but interspersed with areas of irregularity with frayed appearance at the capsule margin.

Conclusions: The PPC device is capable of creating reproducible, central, and precise circular capsulotomy. The ultrastructural features in ex vivo human capsulotomy specimens generally show eversion of the capsulotomy edge, but in some cases, this was accompanied by areas of irregular capsule margin with frayed edges, likely caused by dissipated thermal energy. The postoperative appearance and SEM features warrant further assessment of the PPC integrity and clinical correlation.


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Tasmanian School of Medicine


Elsevier Science Inc

Place of publication

360 Park Ave South, New York, USA, Ny, 10010-1710

Rights statement

Copyright 2017 by the American Academy of Ophthalmology

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Socio-economic Objectives

Clinical health not elsewhere classified

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