File(s) under permanent embargo
Understanding novel mechanisms of microbial pathogenesis in chronic lung disease: implications for new therapeutic targets
journal contribution
posted on 2023-05-19, 19:10 authored by Mathew Eapen, Sukhwinder SohalSukhwinder SohalAirway infections are considered as one of the vital factors driving the pathophysiology of chronic lung disease with significant influences on disease trajectory. Opportunistic lung microbes in diseased conditions induce excessive exacerbations and contribute to airflow limitation. Though there has been considerable amount of information that ascertains their links with airway inflammation, the intricate interaction in clinical conditions are poorly understood and requires further deciphering. Current therapeutic interventions for such pathologies are few and lack the ability to modulate underlying dysfunctional immunity as well as suppress the excessive infectious conditions. Thus, in this Commentary we provide a focused outlook on the mechanisms involved in microbial infestation in lung diseases and provides important information on new therapeutic interventions including the potential role of Resolvins and their derivatives as alternative therapeutic agents in combating such multifaceted pathological mechanisms.
Funding
Clifford Craig Foundation
History
Publication title
Clinical scienceVolume
132Pagination
375-379ISSN
0143-5221Department/School
School of Health SciencesPublisher
Medical Research SocietyPlace of publication
United KingdomRights statement
Copyright 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical SocietyRepository Status
- Restricted