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United colours of chromatin? Developmental genome organisation in flies
journal contribution
posted on 2023-05-20, 06:43 authored by Caroline DelandreCaroline Delandre, Owen MarshallOwen MarshallThe organisation of DNA into differing forms of packaging, or chromatin, controls many of the cell fate decisions during development. Although early studies focused on individual forms of chromatin, in the last decade more holistic studies have attempted to determine a complete picture of the different forms of chromatin present within a cell. In the fruit fly, Drosophila melanogaster, the study of chromatin states has been aided by the use of complementary and cell-type-specific techniques that profile the marks that recruit chromatin protein binding or the proteins themselves. Although many questions remain unanswered, a clearer picture of how different chromatin states affect development is now emerging, with more unusual chromatin states such as Black chromatin playing key roles. Here, we discuss recent findings regarding chromatin biology in flies.
Funding
National Health & Medical Research Council
History
Publication title
Biochemical Society TransactionsVolume
47Pagination
691-700ISSN
0300-5127Department/School
Menzies Institute for Medical ResearchPublisher
Portland PressPlace of publication
59 Portland Place, London, England, W1N 3AjRights statement
© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical SocietyRepository Status
- Restricted