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Vaccinia virus-mediated damage of murine ovaries and protection by virus-expressed interleukin-2
journal contributionposted on 2023-05-20, 21:06 authored by Gunasegaran KarupiahGunasegaran Karupiah, Coupar, B, Ramshaw, I, Boyle, D, Blanden, R, Andrew, M
Vaccinia virus was shown to replicate in the ovaries of normal inbred mice and cause sufficient damage to ovarian follicles to decrease fertility of the mice. The mouse-adapted strain, VV-WR, had a greater affinity for growth in ovaries than the vaccine strains, VV-Elstree, VV-NYBH or VV-Copenhagen. Virus reached the ovaries after intravenous or intraperitoneal inoculation, but not after subcutaneous inoculation in the foot pad. Interleukin-2 (IL-2), when expressed by a recombinant vaccinia virus was able to decrease the titre of virus in the ovaries and prevent infertility. Both non-specific (natural killer cells) and antigen-specific mechanisms were active within the ovaries and may play a role in the IL-2-mediated clearance of vaccinia virus.
Publication titleImmunology and Cell Biology
Department/SchoolTasmanian School of Medicine
PublisherBlackwell Publishing Asia
Place of publication54 University St, P O Box 378, Carlton, Australia, Victoria, 3053
Rights statementCopyright 2010 Australasian Society for Immunology Inc.